![vishnubhatla krishnaveni vishnubhatla krishnaveni](https://4.bp.blogspot.com/-DPjeTE2wMLI/V-96i5MBcWI/AAAAAAAAAWg/_QNAX4UMnrserZuniOFlcNAMVt4DNScrwCLcB/s1600/7.jpg)
The cells isolated showed MSC like morphology, specific marker profile and differentiation potential. They were assessed for doubling time, proliferation, senescence and genetic stability. Passage three cells were characterized for MSC markers (CD90,73,105) and differentiation potential to osteoblasts, adipocytes and chondrocytes. Bone marrow was obtained from cirrhosis patients and MSCs were isolated and cultured. The objective of this study was to characterize the suitability of MSCs derived from bone marrow of CLD patients for autologous transplantation. Mesenchymal stem cell transplantation is considered beneficial due to their immunomodulatory and regenerative properties. With ever-growing demand and long waiting period on the transplant lists worldwide, cell based support therapies had emerged as a bridge to the liver transplantation. Liver transplantation is the gold standard therapy for patients with chronic liver disease (CLD). Further, combination of CysC into the components of MELD score the (“MELD Cystatin”:10* (1.1*Log (INR)+1.378*Log (Cystatin)+0.486*Log (Bilirubin)+0.833*Log (creatinine) +0)+0.5) improved it’s prognostic accuracy (C-Index 0.86 vs.
![vishnubhatla krishnaveni vishnubhatla krishnaveni](https://renjiveda.files.wordpress.com/2012/06/vbsisters.jpg)
A predictive score was developed (CyBAC-Del: 0.039* T bilirubin −0.697* Albumin+1.117* Cystatin+0.817* Creatinine) which had a better AUC (0.776) when compared to sC圜 (0.69) and sCr alone (0.59) ( p<.001) for prediction of first AKI. 0.59 p<0.05) and AKI progression respectively. On multivariate analysis, sC圜 was a better predictor when compared to sCr to predict development of first AKI (AUROC 0.69 vs.
![vishnubhatla krishnaveni vishnubhatla krishnaveni](https://i.ytimg.com/vi/z153t2QnU3o/hqdefault.jpg)
A total of 178 episodes of new AKI were noted at a median time of 43 days (IQR 16–142) in Gr B and 193 days (IQR 107–263) in Gr.A.